Ketones: the claims, the evidence, the application

In this lecture series on "Ketones", expert speaker Dr Chiel Poffé examines the physiology of ketones, the differences between exogenous and endogenous ketones, and their links to lactate, carbohydrate metabolism, and endurance performance. He also unpacks the research study-by-study to explain why findings often conflict and what practitioners should focus on when interpreting the evidence.

What we will cover:
  What are ketones, and how do exogenous and endogenous ketones differ?
  Can ketones enhance endurance performance, efficiency, or cognition?
  Why do ketone studies often produce conflicting findings?
  How do dose, timing, and formulation affect the response to ketones?
  How should practitioners interpret the evidence and apply it in practice?

Dr Chiel Poffé

Chiel Poffé is an Assistant Professor at the Faculty of Rehabilitation Sciences at Hasselt University (Belgium). His research focuses on the mechanisms underlying skeletal muscle adaptations to exercise, training, and rehabilitation, as well as their interaction with nutrition.

He obtained his PhD at the Exercise Physiology Research Group at KU Leuven, where he investigated the impact of ketone ester supplementation on exercise performance and training adaptations. Throughout his postdoc, he further focused on the muscular impact of ketone bodies and performed long-term research stays at the laboratories of Prof. Keith Baar (UC Davis) and prof. Luc van Loon (Maastricht University).

Since 2024, he has established his own laboratory at UHasselt, aiming to bridge muscle biology with applied performance and rehabilitation contexts to better understand the mechanisms driving functional adaptations to exercise and (rehabilitation) training. In parallel, he maintains active scientific collaborations with multiple professional sports teams. This includes the Soudal-Quick-Step WorldTour cycling team, with whom he conducts prospective studies that directly inform elite sport practice.

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