Metabolic flexibility

Metabolic flexibility is one of the most used terms in exercise and nutrition science. Some claim metabolic flexibility is the key to health. Others say it explains elite endurance performance. In some circles, it has become almost synonymous with low-carb and ketogenic diets. But what does the science actually say? Who better to ask then world-leading researcher Professor Bret Goodpaster who is considered one of the founders of the concept 25 years ago.

What we will cover: 
    What is metabolic flexibility, and how has the concept evolved over time?
     How is metabolic flexibility measured, and what are the strengths and limitations?
     Why does metabolic flexibility matter for health and exercise performance?
     What are the most common myths and misconceptions about metabolic flexibility?
     What is meant by "the athlete's paradox"?
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Speakers
1
Number of lectures
3
Video time
90
Reading
3
Exams
0

Professor Bret Goodpaster

Professor Bret Goodpaster’s primary research is in the pathophysiology of obesity, insulin resistance, diabetes, and aging, and to help decipher biological mechanisms underlying the health benefits of weight loss and exercise. He has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008, for his work investigating the role of muscle fat infiltration in aging and muscle quality. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in Type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others?

Dr. Goodpaster has published over 300 peer-reviewed papers, review articles and book chapters, and his papers have received more than 45,000 citations (h-index 101). He currently serves as a PI on the Molecular Transducers of Physical Activity Consortium (MoTrPAC). He has also served on several NIH grant review panels. Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University in 1995.
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